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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

SHP2 Drives Inflammation-triggered Insulin Resistance by Reshaping Tissue Macrophage Populations

Insulin resistance is a key event in type 2 diabetes onset and a major comorbidity of obesity. It results from a combination of fat excess–triggered defects, including lipotoxicity and metaflammation, but the causal mechanisms remain difficult to …

Chromatin 3D Interaction Analysis of the STARD10 Locus Unveils FCHSD2 as a Regulator of Insulin Secretion

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Monogenic Diabetes Characteristics in a Transnational Multicenter Study From Mediterranean Countries

Pathogenic Variants in Actionable MODY Genes are Associated with Type 2 Diabetes

Gene-Educational Attainment Interactions in a Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci

Histone Deacetylase 9 Promoter Hypomethylation Associated with Adipocyte Dysfunction is a Statin-Related Metabolic Effect

General Regression Model: A “Model-Free” Association Test for Quantitative Traits Allowing to Test for the Underlying Genetic Model

Most genome-wide association studies used genetic-model-based tests assuming an additive mode of inheritance, leading to underpowered association tests in case of departure from additivity. The general regression model (GRM) association test proposed …

Loss-of-Function Mutations in MRAP2 Are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension

Large-scale sequencing of coding exons of MRAP2 in 9,418 adults and adolescents identifies loss-of-function mutations that are associated with monogenic obesity, hypertension and hyperglycemia.