Humans

Low-Dose Exposure to Bisphenols A, F and S of Human Primary Adipocyte Impacts Coding and Non-Coding RNA Profiles

Bisphenol A (BPA) exposure has been suspected to be associated with deleterious effects on health including obesity and metabolically-linked diseases. Although bisphenols F (BPF) and S (BPS) are BPA structural analogs commonly used in many marketed …

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, …

Relationship Between Salivary/Pancreatic Amylase and Body Mass Index: A Systems Biology Approach

BACKGROUND: Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR …