Publications (8 + 41)

Issued Title Journal First Last
November,
2024 		A framework for conducting GWAS using repeated measures data with an application to childhood BMI Nature Communications     As last or co-last
August,
2024 		Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function Nature Communications        
August,
2024 		PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism Diabetes        
March,
2024 		Genetic drivers of heterogeneity in type 2 diabetes pathophysiology Nature        
September,
2023 		Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery European Journal of Endocrinology        
May,
2023 		Identification of biomarkers for glycaemic deterioration in type 2 diabetes Nature Communications        
March,
2023 		Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: A case-control study The Lancet Diabetes & Endocrinology        
July,
2022 		Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort Diabetes & Metabolism        
June,
2022 		Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates International Journal of Molecular Sciences        
May,
2022 		Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Nature Genetics        
April,
2022 		Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan Diabetes        
March,
2022 		Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies Diabetes Care        
February,
2022 		Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes Human Molecular Genetics        
January,
2022 		Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study Cell Reports Medicine        
November,
2021 		Elevated circulating follistatin associates with an increased risk of type 2 diabetes Nature Communications        
October,
2021 		Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants ACS Pharmacology & Translational Science        
September,
2021 		Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome Diabetes Care As first or co-first    
June,
2021 		Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci Molecular Psychiatry        
April,
2021 		SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations Science Translational Medicine        
February,
2021 		Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion Cell Reports        
January,
2021 		Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries Diabetes Research and Clinical Practice        
December,
2020 		Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes Cell Reports        
December,
2020 		Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect Clinical Epigenetics        
October,
2020 		Pathogenic variants in actionable MODY genes are associated with type 2 diabetes Nature Metabolism        
May,
2020 		General regression model: A “model‐free” association test for quantitative traits allowing to test for the underlying genetic model Annals of Human Genetics        
February,
2020 		NACHO: An R package for quality control of NanoString nCounter data Bioinformatics As first or co-first    
February,
2020 		The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward International Journal of Obesity        
November,
2019 		Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension Nature Medicine        
October,
2019 		A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Human Molecular Genetics        
August,
2019 		A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Human Molecular Genetics        
July,
2019 		Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals Scientific Reports        
June,
2019 		Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes Molecular Metabolism As first or co-first    
June,
2019 		Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions American Journal of Epidemiology        
June,
2019 		A catalog of genetic loci associated with kidney function from analyses of a million individuals Nature Genetics        
April,
2019 		Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids Nature Genetics        
January,
2019 		Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity Nature Communications        
November,
2018 		Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps Nature Genetics        
August,
2018 		Type 2 diabetes–associated variants of the MT \(_{\textrm{2}}\) melatonin receptor affect distinct modes of signaling Science Signaling        
July,
2018 		Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes Diabetes As first or co-first    
June,
2018 		Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries PLOS ONE        
June,
2018 		Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal and Time-to-Event Trait: An Application to Type 2 Diabetes and Fasting Plasma Glucose Frontiers in Genetics As first or co-first    
April,
2018 		Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes Nature Genetics        
March,
2018 		A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure The American Journal of Human Genetics        
December,
2017 		Relationship between salivary/pancreatic amylase and body mass index: A systems biology approach BMC Medicine        
June,
2017 		Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles PLOS ONE As first or co-first    
June,
2017 		Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion Molecular Metabolism As first or co-first    
February,
2017 		Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice The American Journal of Human Genetics        
January,
2017 		Hepatic DPP4 DNA Methylation Associates With Fatty Liver Diabetes        
April,
2016 		Variable Clustering in High-Dimensional Linear Regression: The R Package clere The R Journal        
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