Publications (8 + 41) – Mickaël CANOUIL

2024 four publications 4 articles

Article★ As last or co-last author19/20November 2024

Burrows, K., Heiskala, A., Bradfield, J. P., Balkhiyarova, Z., Ning, L., Boissel, M., Chan, Y. M., Froguel, P., Bonnefond, A., Hakonarson, H., Alves, A. C., Lawlor, D. A., Kaakinen, M., Järvelin, M. R., Grant, S. F. A., Tilling, K., Prokopenko, I., Sebert, S., Canouil, M., Warrington, N. M.

A Framework For Conducting GWAS Using Repeated Measures Data With An Application To Childhood BMI

Nature Communications, vol. 15, no. 1, pp. 10067

Article27/30August 2024

Meulebrouck, S., Merrheim, J., Queniat, G., Bourouh, C., Derhourhi, M., Boissel, M., Yi, X., Badreddine, A., Boutry, R., Leloire, A., Toussaint, B., Amanzougarene, S., Vaillant, E., Durand, E., Loiselle, H., Huyvaert, M., Dechaume, A., Scherrer, V., Marchetti, P., Balkau, B., Charpentier, G., Franc, S., Marre, M., Roussel, R., Scharfmann, R., Cnop, M., Canouil, M., Baron, M., Froguel, P., Bonnefond, A.

Functional Genetics Reveals The Contribution Of Delta Opioid Receptor To Type 2 Diabetes And Beta-Cell Function

Nature Communications, vol. 15, no. 1, pp. 6627

Article18/22August 2024

Maurin, L., Marselli, L., Boissel, M., Ning, L., Boutry, R., Fernandes, J., Suleiman, M., De Luca, C., Leloire, A., Pascat, V., Toussaint, B., Amanzougarene, S., Derhourhi, M., Jörns, A., Lenzen, S., Pattou, F., Kerr-Conte, J., Canouil, M., Marchetti, P., Bonnefond, A., Froguel, P., Khamis, A.

PNLIPRP1 Hypermethylation In Exocrine Pancreas Links Type 2 Diabetes And Cholesterol Metabolism

Diabetes, pp. db240215

Article91/374March 2024

Suzuki, K., Hatzikotoulas, K., Southam, L., …, Canouil, M., …, Zeggini, E.

Genetic Drivers Of Heterogeneity In Type 2 Diabetes Pathophysiology

Nature, vol. 627, no. 8003, pp. 347-357

2023 three publications 3 articles

Article2/13September 2023

Orioli, L., Canouil, M., Sawadogo, K., Ning, L., Deldicque, L., Lause, P., de Barsy, M., Froguel, P., Loumaye, A., Deswysen, Y., Navez, B., Bonnefond, A., Thissen, J. P.

Identification Of Myokines Susceptible To Improve Glucose Homeostasis After Bariatric Surgery

European Journal of Endocrinology, vol. 189, no. 3, pp. 409-421

Article21/66May 2023

Slieker, R. C., Donnelly, L. A., Akalestou, E., …, Canouil, M., …, Rutter, G. A.

Identification Of Biomarkers For Glycaemic Deterioration In Type 2 Diabetes

Nature Communications, vol. 14, no. 1, pp. 2533

Article16/19March 2023

Folon, L., Baron, M., Toussaint, B., Vaillant, E., Boissel, M., Scherrer, V., Loiselle, H., Leloire, A., Badreddine, A., Balkau, B., Charpentier, G., Franc, S., Marre, M., Aboulouard, S., Salzet, M., Canouil, M., Derhourhi, M., Froguel, P., Bonnefond, A.

Contribution Of Heterozygous PCSK1 Variants To Obesity And Implications For Precision Medicine: A Case-Control Study

The Lancet Diabetes & Endocrinology, vol. 11, no. 3, pp. 182-190

2022 seven publications 7 articles

Article5/7July 2022

Khamis, A., Ning, L., Balkau, B., Bonnefond, A., Canouil, M., Roussel, R., Froguel, P.

Epigenetic Changes Associated With Hyperglycaemia Exposure In The Longitudinal D.E.S.I.R. Cohort

Diabetes & Metabolism, vol. 48, no. 4, pp. 101347

Article4/12June 2022

Pelletier, A., Carrier, A., Zhao, Y., Canouil, M., Derhourhi, M., Durand, E., Berberian-Ferrato, L., Greally, J., Hughes, F., Froguel, P., Bonnefond, A., Delahaye, F.

Epigenetic And Transcriptomic Programming Of HSC Quiescence Signaling In Large For Gestational Age Neonates

International Journal of Molecular Sciences, vol. 23, no. 13, pp. 7323

Article91/355May 2022

Mahajan, A., Spracklen, C. N., Zhang, W., …, Canouil, M., …, Morris, A. P.

Multi-Ancestry Genetic Study Of Type 2 Diabetes Highlights The Power Of Diverse Populations For Discovery And Translation

Nature Genetics, vol. 54, no. 5, pp. 560-572

Article12/16April 2022

Saeed, S., Janjua, Q. M., Haseeb, A., Khanam, R., Durand, E., Vaillant, E., Ning, L., Badreddine, A., Berberian, L., Boissel, M., Amanzougarene, S., Canouil, M., Derhourhi, M., Bonnefond, A., Arslan, M., Froguel, P.

Rare Variant Analysis Of Obesity-Associated Genes In Young Adults With Severe Obesity From A Consanguineous Population Of Pakistan

Diabetes, vol. 71, no. 4, pp. 694-705

Article6/51March 2022

Tobi, E. W., Juvinao-Quintero, D. L., Ronkainen, J., …, Canouil, M., …, Sebert, S.

Maternal Glycemic Dysregulation During Pregnancy And Neonatal Blood DNA Methylation: Meta-Analyses Of Epigenome-Wide Association Studies

Diabetes Care, vol. 45, no. 3, pp. 614-623

Article8/73February 2022

Pervjakova, N., Moen, G. H., Borges, M. C., …, Canouil, M., …, Mägi, R.

Multi-Ancestry Genome-Wide Association Study Of Gestational Diabetes Mellitus Highlights Genetic Links With Type 2 Diabetes

Human Molecular Genetics, vol. 31, no. 19, pp. 3377-3391

Article38/60January 2022

Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., …, Canouil, M., …, Brunak, S.

Four Groups Of Type 2 Diabetes Contribute To The Etiological And Clinical Heterogeneity In Newly Diagnosed Individuals: An IMI DIRECT Study

Cell Reports Medicine, vol. 3, no. 1, pp. 100477

2021 seven publications 7 articles

Article17/42November 2021

Wu, C., Borné, Y., Gao, R., …, Canouil, M., …, De Marinis, Y.

Elevated Circulating Follistatin Associates With An Increased Risk Of Type 2 Diabetes

Nature Communications, vol. 12, no. 1, pp. 6486

Article7/17October 2021

Hegron, A., Huh, E., Deupi, X., Sokrat, B., Gao, W., Le Gouill, C., Canouil, M., Boissel, M., Charpentier, G., Roussel, R., Balkau, B., Froguel, P., Plouffe, B., Bonnefond, A., Lichtarge, O., Jockers, R., Bouvier, M.

Identification Of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed By Natural Variants

ACS Pharmacology & Translational Science, vol. 4, no. 5, pp. 1614-1627

Article★ As first or co-first author1/15September 2021

Canouil, M., Khamis, A., Keikkala, E., Hummel, S., Lobbens, S., Bonnefond, A., Delahaye, F., Tzala, E., Mustaniemi, S., Vääräsmäki, M., Jarvelin, M. R., Sebert, S., Kajantie, E., Froguel, P., Andrew, T.

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure And Maternal Methylome

Diabetes Care, vol. 44, no. 9, pp. 1992-1999

Article74/223June 2021

de las Fuentes, L., Sung, Y. J., Noordam, R., …, Canouil, M., …, Fornage, M.

Gene-Educational Attainment Interactions In A Multi-Ancestry Genome-Wide Meta-Analysis Identify Novel Blood Pressure Loci

Molecular Psychiatry, vol. 26, no. 6, pp. 2111-2125

Article17/33April 2021

Paccoud, R., Saint-Laurent, C., Piccolo, E., …, Canouil, M., …, Yart, A.

SHP2 Drives Inflammation-Triggered Insulin Resistance By Reshaping Tissue Macrophage Populations

Science Translational Medicine, vol. 13, no. 591, pp. eabe2587

Article7/18February 2021

Hu, M., Cebola, I., Carrat, G., Jiang, S., Nawaz, S., Khamis, A., Canouil, M., Froguel, P., Schulte, A., Solimena, M., Ibberson, M., Marchetti, P., Cardenas-Diaz, F. L., Gadue, P. J., Hastoy, B., Almeida-Souza, L., McMahon, H., Rutter, G. A.

Chromatin 3D Interaction Analysis Of The STARD10 Locus Unveils FCHSD2 As A Regulator Of Insulin Secretion

Cell Reports, vol. 34, no. 5, pp. 108703

Article11/24January 2021

Vaxillaire, M., Bonnefond, A., Liatis, S., Ben Salem Hachmi, L., Jotic, A., Boissel, M., Gaget, S., Durand, E., Vaillant, E., Derhourhi, M., Canouil, M., Larcher, N., Allegaert, F., Medlej, R., Chadli, A., Belhadj, A., Chaieb, M., Raposo, J. F., Ilkova, H., Loizou, D., Lalic, N., Vassallo, J., Marre, M., Froguel, P.

Monogenic Diabetes Characteristics In A Transnational Multicenter Study From Mediterranean Countries

Diabetes Research and Clinical Practice, vol. 171, pp. 108553

2020 six publications 6 articles

Article32/36December 2020

Marselli, L., Piron, A., Suleiman, M., …, Canouil, M., …, Marchetti, P.

Persistent Or Transient Human β Cell Dysfunction Induced By Metabolic Stress: Specific Signatures And Shared Gene Expression With Type 2 Diabetes

Cell Reports, vol. 33, no. 9, pp. 108466

Article3/10December 2020

Khamis, A., Boutry, R., Canouil, M., Mathew, S., Lobbens, S., Crouch, H., Andrew, T., Abderrahmani, A., Tamanini, F., Froguel, P.

Histone Deacetylase 9 Promoter Hypomethylation Associated With Adipocyte Dysfunction Is A Statin-Related Metabolic Effect

Clinical Epigenetics, vol. 12, no. 1, pp. 68

Article24/27October 2020

Bonnefond, A., Boissel, M., Bolze, A., Durand, E., Toussaint, B., Vaillant, E., Gaget, S., Graeve, F. D., Dechaume, A., Allegaert, F., Guilcher, D. L., Yengo, L., Dhennin, V., Borys, J. M., Lu, J. T., Cirulli, E. T., Elhanan, G., Roussel, R., Balkau, B., Marre, M., Franc, S., Charpentier, G., Vaxillaire, M., Canouil, M., Washington, N. L., Grzymski, J. J., Froguel, P.

Pathogenic Variants In Actionable MODY Genes Are Associated With Type 2 Diabetes

Nature Metabolism, vol. 2, no. 10, pp. 1126-1134

Article5/12May 2020

Gloaguen, E., Dizier, M., Boissel, M., Rocheleau, G., Canouil, M., Froguel, P., Tichet, J., Roussel, R., The D.E.S.I.R. Study Group, Julier, C., Balkau, B., Mathieu, F.

General Regression Model: A "model‐free" Association Test For Quantitative Traits Allowing To Test For The Underlying Genetic Model

Annals of Human Genetics, vol. 84, no. 3, pp. 280-290

Article★ As first or co-first author1/6February 2020

Canouil, M., Bouland, G. A., Bonnefond, A., Froguel, P., "'t" Hart, L. M., Slieker, R. C.

NACHO: An R Package For Quality Control Of NanoString [NCounter]{.nocase} Data

Bioinformatics, vol. 36, no. 3, pp. 970-971

Article4/17February 2020

Ndiaye, F. K., Huyvaert, M., Ortalli, A., Canouil, M., Lecoeur, C., Verbanck, M., Lobbens, S., Khamis, A., Marselli, L., Marchetti, P., Kerr-Conte, J., Pattou, F., Marre, M., Roussel, R., Balkau, B., Froguel, P., Bonnefond, A.

The Expression Of Genes In Top Obesity-Associated Loci Is Enriched In Insula And Substantia Nigra Brain Regions Involved In Addiction And Reward

International Journal of Obesity, vol. 44, no. 2, pp. 539-543

2019 nine publications 9 articles

Article29/31November 2019

Baron, M., Maillet, J., Huyvaert, M., …, Canouil, M., …, Bonnefond, A.

Loss-Of-Function Mutations In MRAP2 Are Pathogenic In Hyperphagic Obesity With Hyperglycemia And Hypertension

Nature Medicine, vol. 25, no. 11, pp. 1733-1738

Article41/99October 2019

Bradfield, J. P., Vogelezang, S., Felix, J. F., …, Canouil, M., …, Struan F A Grant for the Early Growth Genetics Consortium

A Trans-Ancestral Meta-Analysis Of Genome-Wide Association Studies Reveals Loci Associated With Childhood Obesity

Human Molecular Genetics, vol. 28, no. 19, pp. 3327-3338

Article94/282August 2019

Sung, Y. J., de las Fuentes, L., Winkler, T. W., …, Canouil, M., …, Morrison, A. C.

A Multi-Ancestry Genome-Wide Study Incorporating Gene--Smoking Interactions Identifies Multiple New Loci For Pulse Pressure And Mean Arterial Pressure

Human Molecular Genetics, vol. 28, no. 15, pp. 2615-2633

Article7/50July 2019

Liu, C. T., Merino, J., Rybin, D., …, Canouil, M., …, Bouatia-Naji, N.

Genome-Wide Association Study Of Change In Fasting Glucose Over Time In 13,807 Non-Diabetic European Ancestry Individuals

Scientific Reports, vol. 9, no. 1, pp. 9439

Article★ As first or co-first author2/20June 2019

Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. V., Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M., Froguel, P.

Laser Capture Microdissection Of Human Pancreatic Islets Reveals Novel [EQTLs]{.nocase} Associated With Type 2 Diabetes

Molecular Metabolism, vol. 24, pp. 98-107

Article81/268June 2019

de Vries, P. S., Brown, M. R., Bentley, A. R., …, Canouil, M., …, Morrison, A. C.

Multiancestry Genome-Wide Association Study Of Lipid Levels Incorporating Gene-Alcohol Interactions

American Journal of Epidemiology, vol. 188, no. 6, pp. 1033-1054

Article51/300June 2019

Wuttke, M., Li, Y., Li, M., …, Canouil, M., …, V. A. Million Veteran Program

A Catalog Of Genetic Loci Associated With Kidney Function From Analyses Of A Million Individuals

Nature Genetics, vol. 51, no. 6, pp. 957-972

Article101/305April 2019

COGENT-Kidney Consortium, EPIC-InterAct Consortium, Understanding Society Scientific Group, …, Canouil, M., …, Cupples, L. A.

Multi-Ancestry Genome-Wide Gene--Smoking Interaction Study Of 387,272 Individuals Identifies New Loci Associated With Serum Lipids

Nature Genetics, vol. 51, no. 4, pp. 636-648

Article74/238January 2019

Kilpeläinen, T. O., Bentley, A. R., Noordam, R., …, Canouil, M., …, Loos, R. J. F.

Multi-Ancestry Study Of Blood Lipid Levels Identifies Four Loci Interacting With Physical Activity

Nature Communications, vol. 10, no. 1, pp. 376

2018 seven publications 7 articles

Article35/115November 2018

Mahajan, A., Taliun, D., Thurner, M., …, Canouil, M., …, McCarthy, M. I.

Fine-Mapping Type 2 Diabetes Loci To Single-Variant Resolution Using High-Density Imputation And Islet-Specific Epigenome Maps

Nature Genetics, vol. 50, no. 11, pp. 1505-1513

Article9/17August 2018

Karamitri, A., Plouffe, B., Bonnefond, A., Chen, M., Gallion, J., Guillaume, J. L., Hegron, A., Boissel, M., Canouil, M., Langenberg, C., Wareham, N. J., Le Gouill, C., Lukasheva, V., Lichtarge, O., Froguel, P., Bouvier, M., Jockers, R.

Type 2 Diabetes--Associated Variants Of The MT $_{\textrm{2}}$ Melatonin Receptor Affect Distinct Modes Of Signaling

Science Signaling, vol. 11, no. 545, pp. eaan6622

Article★ As first or co-first author4/38July 2018

Abderrahmani, A., Yengo, L., Caiazzo, R., Canouil, M., …, Froguel, P.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance In Obesity-Associated Type 2 Diabetes

Diabetes, vol. 67, no. 7, pp. 1310-1321

Article87/274June 2018

Feitosa, M. F., Kraja, A. T., Chasman, D. I., …, Canouil, M., …, Levy, D.

Novel Genetic Associations For Blood Pressure Identified Via Gene-Alcohol Interaction In Up To 570K Individuals Across Multiple Ancestries

PLOS ONE, vol. 13, no. 6, pp. e0198166

Article★ As first or co-first author1/5June 2018

Canouil, M., Balkau, B., Roussel, R., Froguel, P., Rocheleau, G.

Jointly Modelling Single Nucleotide Polymorphisms With Longitudinal And Time-To-Event Trait: An Application To Type 2 Diabetes And Fasting Plasma Glucose

Frontiers in Genetics, vol. 9, pp. 210

Article68/243April 2018

Mahajan, A., Wessel, J., Willems, S. M., …, Canouil, M., …, McCarthy, M. I.

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

Nature Genetics, vol. 50, no. 4, pp. 559-571

Article94/297March 2018

Sung, Y. J., Winkler, T. W., de las Fuentes, L., …, Canouil, M., …, Chasman, D. I.

A Large-Scale Multi-Ancestry Genome-Wide Study Accounting For Smoking Behavior Identifies Multiple Significant Loci For Blood Pressure

The American Journal of Human Genetics, vol. 102, no. 3, pp. 375-400

2017 five publications 5 articles

Article4/20December 2017

Bonnefond, A., Yengo, L., Dechaume, A., Canouil, M., Castelain, M., Roger, E., Allegaert, F., Caiazzo, R., Raverdy, V., Pigeyre, M., Arredouani, A., Borys, J. M., Lévy-Marchal, C., Weill, J., Roussel, R., Balkau, B., Marre, M., Pattou, F., Brousseau, T., Froguel, P.

Relationship Between Salivary/pancreatic Amylase And Body Mass Index: A Systems Biology Approach

BMC Medicine, vol. 15, no. 1, pp. 37

Article★ As first or co-first author2/8June 2017

Verbanck, M., Canouil, M., Leloire, A., Dhennin, V., Coumoul, X., Yengo, L., Froguel, P., Poulain-Godefroy, O.

Low-Dose Exposure To Bisphenols A, F And S Of Human Primary Adipocyte Impacts Coding And Non-Coding RNA Profiles

PLOS ONE, vol. 12, no. 6, pp. e0179583

Article★ As first or co-first author3/22June 2017

Ndiaye, F. K., Ortalli, A., Canouil, M., Huyvaert, M., Salazar-Cardozo, C., Lecoeur, C., Verbanck, M., Pawlowski, V., Boutry, R., Durand, E., Rabearivelo, I., Sand, O., Marselli, L., Kerr-Conte, J., Chandra, V., Scharfmann, R., Poulain-Godefroy, O., Marchetti, P., Pattou, F., Abderrahmani, A., Froguel, P., Bonnefond, A.

Expression And Functional Assessment Of Candidate Type 2 Diabetes Susceptibility Genes Identify Four New Genes Contributing To Human Insulin Secretion

Molecular Metabolism, vol. 6, no. 6, pp. 459-470

Article10/26February 2017

Carrat, G. R., Hu, M., Nguyen-Tu, M. S., Chabosseau, P., Gaulton, K. J., van de Bunt, M., Siddiq, A., Falchi, M., Thurner, M., Canouil, M., Pattou, F., Leclerc, I., Pullen, T. J., Cane, M. C., Prabhala, P., Greenwald, W., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P. E., Manning Fox, J. E., Gloyn, A. L., Froguel, P., Solimena, M., McCarthy, M. I., Rutter, G. A.

Decreased STARD10 Expression Is Associated With Defective Insulin Secretion In Humans And Mice

The American Journal of Human Genetics, vol. 100, no. 2, pp. 238-256

Article7/17January 2017

Baumeier, C., Saussenthaler, S., Kammel, A., Jähnert, M., Schlüter, L., Hesse, D., Canouil, M., Lobbens, S., Caiazzo, R., Raverdy, V., Pattou, F., Nilsson, E., Pihlajamäki, J., Ling, C., Froguel, P., Schürmann, A., Schwenk, R. W.

Hepatic DPP4 DNA Methylation Associates With Fatty Liver

Diabetes, vol. 66, no. 1, pp. 25-35

2016 one publication 1 article

Article4/4April 2016

Yengo, L., Jacques, J., Biernacki, C., Canouil, M.

Variable Clustering In High-Dimensional Linear Regression: The R Package Clere

The R Journal, vol. 8, no. 1, pp. 92